| Function | Catalyzes the transfer of galactose from UDP-alpha-D-galactose to lactosylceramide/beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide(d18:1(4E)) to produce globotriaosylceramide/globoside Gb3Cer (d18:1(4E)). Also able to transfer galactose to galactosylceramide/beta-D-Gal-(1<->1')-Cer. Globoside Gb3Cer is a glycosphingolipid of the globo serie, one of the major types of neutral root structures of glycosphingolipids, that constitute a significant portion of mammalian cell membranes (Probable). Globotriaosylceramide/globoside Gb3Cer in blood and tissue cell membranes is the antigen Pk of blood histogroup P. (Microbial infection) Globotriaosylceramide is one of the cellular ligands for bacterial verotoxins. |
| Protein Name | Lactosylceramide 4-Alpha-GalactosyltransferaseAlpha-1 -4-N-AcetylglucosaminyltransferaseAlpha-1 -4-GalactosyltransferaseAlpha4gal-T1Cd77 SynthaseGlobotriaosylceramide SynthaseGb3 SynthaseP1/Pk SynthaseUdp-Galactose -Beta-D-Galactosyl-Beta1-R 4-Alpha-D-Galactosyltransferase |
| Database Links | Reactome: R-HSA-9840309 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Protein Names | Lactosylceramide 4-Alpha-Galactosyltransferase proteinAlpha-1 -4-N-Acetylglucosaminyltransferase proteinAlpha-1 -4-Galactosyltransferase proteinAlpha4gal-T1 proteinCd77 Synthase proteinGlobotriaosylceramide Synthase proteinGb3 Synthase proteinP1/Pk Synthase proteinUdp-Galactose -Beta-D-Galactosyl-Beta1-R 4-Alpha-D-Galactosyltransferase proteinA4GALT proteinA14GALT proteinA4GALT1 protein |
Information sourced from Uniprot.org
