Human CD248/TEM1 protein (Recombinant-Active) (C-His) (STJP012273)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human CD248/TEM1-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | Measured by its binding ability in a functional ELISA. When recombinant human CD248/TEM1 is Immobilised at 2 Mu g/mL (100 Mu L/well) , the concentration of recombinant human Galectin‑3BP/MAC‑2BP that produces 50% of the optimal binding response is ap |
Target Information
| Gene Symbol | CD248 |
| Gene ID | 57124 |
| Uniprot ID | CD248_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gln18-Arg685 |
Additional Info
| Post Translational Modifications | O-glycosylated with sialylated oligosaccharides. May be N-glycosylated. |
| Function | Cell surface glycoprotein involved in various biological processes including angiogenesis, immune response modulation, and tissue remodeling and repair. Participates in pericyte proliferation through positive modulation of the PDGF receptor signaling pathway. Acts as a scaffold for factor X, triggering allosteric changes and the spatial re-alignment of factor X with the TF-factor VIIa complex, thereby enhancing coagulation activation. Modulates the insulin signaling pathway by interacting with insulin receptor/INSR and by diminishing its capacity to be autophosphorylated in response to insulin. Also regulates LPS-induced inflammatory response in macrophages by favoring the production of proinflammatory cytokines. In human, negatively regulates T-cell proliferation compared with stromal cells where it increases proliferation. |
| Protein Name | EndosialinTumor Endothelial Marker 1Cd Antigen Cd248 |
| Database Links | |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Endosialin proteinTumor Endothelial Marker 1 proteinCd Antigen Cd248 proteinCD248 proteinCD164L1 proteinTEM1 protein |
Information sourced from Uniprot.org