Human CD124 (IL4Ra) protein (Recombinant) (STJP000488)

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STJP000488
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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CD124 (IL4Ra)-protein was developed from hek293. For use in research applications.
Conjugation: Unconjugated
Formulation: 0.2 Mu m filtered PBS solution, pH7.2.
Storage Instruction: Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA
Gene Symbol: IL4R
Gene ID: 3566
Uniprot ID: IL4RA_HUMAN
Immunogen Region: ECD
Immunogen: Optimized DNA sequence encoding Human extracellular domain of human CD124including a C-terminal 6His tag was expressed in HEK293 cells. NA
Tissue Specificity Isoform 1 and isoform 2 are highly expressed in activated T-cells.
Post Translational Modifications On IL4 binding, phosphorylated on C-terminal tyrosine residues. Phosphorylation on any one of tyrosine residues, Tyr-575, Tyr-603 or Tyr-631, is required for STAT6-induced gene induction. The soluble form (sIL4R/IL4BP) can also be produced by proteolytic cleavage at the cell surface (shedding) by a metalloproteinase.
Function Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells.
Protein Name Interleukin-4 Receptor Subunit Alpha
Il-4 Receptor Subunit Alpha
Il-4r Subunit Alpha
Il-4r-Alpha
Il-4ra
Cd Antigen Cd124 Cleaved Into - Soluble Interleukin-4 Receptor Subunit Alpha
Soluble Il-4 Receptor Subunit Alpha
Soluble Il-4r-Alpha
Sil4ralpha/Prot
Il-4-Binding Protein
Il4-Bp
Database Links Reactome: R-HSA-6785807
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 2: Secreted
Alternative Protein Names Interleukin-4 Receptor Subunit Alpha protein
Il-4 Receptor Subunit Alpha protein
Il-4r Subunit Alpha protein
Il-4r-Alpha protein
Il-4ra protein
Cd Antigen Cd124 Cleaved Into - Soluble Interleukin-4 Receptor Subunit Alpha protein
Soluble Il-4 Receptor Subunit Alpha protein
Soluble Il-4r-Alpha protein
Sil4ralpha/Prot protein
Il-4-Binding Protein protein
Il4-Bp protein
IL4R protein
IL4RA protein
582J2.1 protein

Information sourced from Uniprot.org

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