Function | Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of pro-inflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes. |
Protein Name | Semaphorin-7aCdw108Jmh Blood Group AntigenJohn-Milton-Hargen Human Blood Group AgSemaphorin-K1Sema K1Semaphorin-LSema LCd Antigen Cd108 |
Database Links | Reactome: R-HSA-416700 |
Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorExtracellular SideDetected In A Punctate Pattern On The Cell Membrane Of Basal And Supra-Basal Skin Keratinocytes |
Alternative Protein Names | Semaphorin-7a proteinCdw108 proteinJmh Blood Group Antigen proteinJohn-Milton-Hargen Human Blood Group Ag proteinSemaphorin-K1 proteinSema K1 proteinSemaphorin-L proteinSema L proteinCd Antigen Cd108 proteinSEMA7A proteinCD108 proteinSEMAL protein |
Information sourced from Uniprot.org