Human CCL8/MCP-2 protein (Recombinant) (No-Tag) (STJP003000)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenRecombinant Human CCL8/MCP-2 Protein by Pichia expression system. The target protein is expressed with sequence (Gln24-Pro99) of Human CCL8/MCP-2 (Accession #NP_005614.2) fused with No tag.
General Information
| Short Description | Recombinant-Human CCL8/MCP-2-No-Tag protein was developed in e.coli using the region Gln24-Pro99. For use in research applications. |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from 0.22 Mu m filtered solution in PBS (pH 7.4). Normally 8% Trehalose is added as protectant before lyophilisation. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | <0.1 EU/Mu g |
Target Information
| Gene Symbol | CCL8 |
| Gene ID | 6355 |
| Uniprot ID | CCL8_HUMAN |
| Immunogen | Recombinant Human CCL8/MCP-2 Protein by Pichia expression system. The target protein is expressed with sequence (Gln24-Pro99) of Human CCL8/MCP-2 (Accession #NP_005614.2) fused with No tag. |
| Immunogen Region | Gln24-Pro99 |
| Immunogen Sequence | ASLAADTPTACCFSYTSRQI PQNFIADYFETSSQCSKPGV IFLTKRSRQVCADPSEEWVQ KYVSDLELSA |
Additional Info
| Tissue Specificity | Highest expression found in the small intestine and peripheral blood cells. Intermediate levels seen in the heart, placenta, lung, skeletal muscle, thymus, colon, ovary, spinal cord and pancreas. Low levels seen in the brain, liver, spleen and prostate. |
| Post Translational Modifications | N-terminal processed form MCP-2(6-76) is produced by proteolytic cleavage after secretion from peripheral blood monocytes. |
| Function | Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8. |
| Protein Name | C-C Motif Chemokine 8Hc14Monocyte Chemoattractant Protein 2Monocyte Chemotactic Protein 2Mcp-2Small-Inducible Cytokine A8 Cleaved Into - Mcp-2(6-76 |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Protein Names | C-C Motif Chemokine 8 proteinHc14 proteinMonocyte Chemoattractant Protein 2 proteinMonocyte Chemotactic Protein 2 proteinMcp-2 proteinSmall-Inducible Cytokine A8 Cleaved Into - Mcp-2(6-76 proteinCCL8 proteinMCP2 proteinSCYA10 proteinSCYA8 protein |
Information sourced from Uniprot.org