| Short Description : | Recombinant-Human CCL25/TECK-C-His protein was developed in hek293 cells using the region Gln24-Leu150. For use in research applications. |
| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | CCL25 |
| Gene ID: | 6370 |
| Uniprot ID: | CCL25_HUMAN |
| Immunogen: | Recombinant Human CCL25/TECK Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln24-Leu150 ) of Human CCL25/TECK (Accession #NP_000726.1&NP_005615.2) fused with a His tag at the C-terminus. |
| Immunogen Region: | Gln24-Leu150 |
| Immunogen Sequence: | ARGTNVGRECCLEYFKGAIP LRKLKTWYQTSEDCSRDAIV FVTVQGRAICSDPNNKRVKN AVKYLQSLERS |
| Tissue Specificity | Specifically expressed by thymic dendritic cells. High levels in thymus and small intestine. |
| Function | Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. |
| Protein Name | C-C Motif Chemokine 25Chemokine TeckSmall-Inducible Cytokine A25Thymus-Expressed Chemokine |
| Database Links | Reactome: R-HSA-380108Reactome: R-HSA-418594 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | C-C Motif Chemokine 25 proteinChemokine Teck proteinSmall-Inducible Cytokine A25 proteinThymus-Expressed Chemokine proteinCCL25 proteinSCYA25 proteinTECK protein |
Information sourced from Uniprot.org
