Recombinant protein Human CCL23/Ck beta 8-1 was determined by SDS-PAGE under reducing conditions with Coomassie Blue, showing a band at 15-25 kDa.

Human CCL23/Ck beta 8-1 protein (Recombinant) (No tag) (STJP002903)

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STJP002903
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Host: E.coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.2 Mu m filtered solution of 20 mM PB, 250 mM NaCl, pH 7.2.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 1 EU/Mu g of the protein by LAL method.
Gene Symbol: CCL23
Gene ID: 6368
Uniprot ID: CCL23_HUMAN
Immunogen Region: Arg22-Asn120
Immunogen: Recombinant Human CCL23/Ck beta 8-1 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Arg22-Asn120) of human CCL23/Ck beta 8-1 (Accession #P55773) fused with no additional amino acid.
Immunogen Sequence: NLNPKKFSIHDQDHKVLVLD SGNLIAVPDKNYIRPEIFFA LASSLSSASAEKGSPILLGV SKGEFCLYCDKDKGQSHPSL QLKKEKLMKLAAQKESARRP FIFYRAQVGSWNMLESAAHP GWFICTSCNCNEPVGVTDKF ENRKHIEFSFQPVCKAEMSP SEVSD
Tissue Specificity High levels in adult lung, liver, skeletal muscle and pancreas. Moderate levels in fetal liver, adult bone marrow and placenta. The short form is the major species and the longer form was detected only in very low abundance. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are found in high levels in synovial fluids from rheumatoid patients.
Post Translational Modifications The N-terminal is proteolytically cleaved by proteases associated with inflammatory responses. The processed forms, CCL23(19-99), CCL23(22-99), CCL23(27-99) and CCL23(30-99) exhibit increase in CCR1-mediated signaling and chemotaxis assays in vitro.
Function Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than CCL23.
Protein Name C-C Motif Chemokine 23
Ck-Beta-8
Ckb-8
Macrophage Inflammatory Protein 3
Mip-3
Myeloid Progenitor Inhibitory Factor 1
Mpif-1
Small-Inducible Cytokine A23 Cleaved Into - Ccl23(19-99 - Ccl23(22-99 - Ccl23(27-99 - Ccl23(30-99
Database Links Reactome: R-HSA-416476 P55773-2
Reactome: R-HSA-418594 P55773-2
Reactome: R-HSA-444473 P55773-2
Cellular Localisation Secreted
Alternative Protein Names C-C Motif Chemokine 23 protein
Ck-Beta-8 protein
Ckb-8 protein
Macrophage Inflammatory Protein 3 protein
Mip-3 protein
Myeloid Progenitor Inhibitory Factor 1 protein
Mpif-1 protein
Small-Inducible Cytokine A23 Cleaved Into - Ccl23(19-99 - Ccl23(22-99 - Ccl23(27-99 - Ccl23(30-99 protein
CCL23 protein
MIP3 protein
MPIF1 protein
SCYA23 protein

Information sourced from Uniprot.org

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