| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human CCL2/MCP-1-C-hFc protein was developed from hek293 cells and has a target region of C-hFc. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CCL2 |
| Gene ID: |
6347 |
| Uniprot ID: |
CCL2_HUMAN |
| Immunogen Region: |
Leu22-Thr99 |
| Immunogen: |
Recombinant Human CCL2/MCP-1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu22-Thr99) of human CCL2/MCP-1 (Accession #NP_002973.1) fused with and a hFc tag at the C-terminus. |
| Post Translational Modifications | Processing at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant. N-Glycosylated. |
| Function | Acts as a ligand for C-C chemokine receptor CCR2. Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions. Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. |
| Protein Name | C-C Motif Chemokine 2Hc11Monocyte Chemoattractant Protein 1Monocyte Chemotactic And Activating FactorMcafMonocyte Chemotactic Protein 1Mcp-1Monocyte Secretory Protein JeSmall-Inducible Cytokine A2 |
| Database Links | Reactome: R-HSA-380108Reactome: R-HSA-380994Reactome: R-HSA-6783783Reactome: R-HSA-6785807 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | C-C Motif Chemokine 2 proteinHc11 proteinMonocyte Chemoattractant Protein 1 proteinMonocyte Chemotactic And Activating Factor proteinMcaf proteinMonocyte Chemotactic Protein 1 proteinMcp-1 proteinMonocyte Secretory Protein Je proteinSmall-Inducible Cytokine A2 proteinCCL2 proteinMCP1 proteinSCYA2 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
