Human CCL2/MCP-1 protein (Recombinant) (C-hFc) (STJP002857)

SKU:
STJP002857

Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human CCL2/MCP-1-C-hFc protein was developed from hek293 cells and has a target region of C-hFc. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CCL2
Gene ID: 6347
Uniprot ID: CCL2_HUMAN
Immunogen Region: Leu22-Thr99
Immunogen: Recombinant Human CCL2/MCP-1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu22-Thr99) of human CCL2/MCP-1 (Accession #NP_002973.1) fused with and a hFc tag at the C-terminus.
Post Translational Modifications Processing at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant. N-Glycosylated.
Function Acts as a ligand for C-C chemokine receptor CCR2. Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions. Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
Protein Name C-C Motif Chemokine 2
Hc11
Monocyte Chemoattractant Protein 1
Monocyte Chemotactic And Activating Factor
Mcaf
Monocyte Chemotactic Protein 1
Mcp-1
Monocyte Secretory Protein Je
Small-Inducible Cytokine A2
Database Links Reactome: R-HSA-380108
Reactome: R-HSA-380994
Reactome: R-HSA-6783783
Reactome: R-HSA-6785807
Cellular Localisation Secreted
Alternative Protein Names C-C Motif Chemokine 2 protein
Hc11 protein
Monocyte Chemoattractant Protein 1 protein
Monocyte Chemotactic And Activating Factor protein
Mcaf protein
Monocyte Chemotactic Protein 1 protein
Mcp-1 protein
Monocyte Secretory Protein Je protein
Small-Inducible Cytokine A2 protein
CCL2 protein
MCP1 protein
SCYA2 protein

Information sourced from Uniprot.org

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