Human CBR1 protein (Recombinant) (N-His) (STJP006583)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CBR1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CBR1 |
| Gene ID | 873 |
| Uniprot ID | CBR1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Trp277 |
Additional Info
| Function | NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue. |
| Protein Name | Carbonyl Reductase Nadph 115-Hydroxyprostaglandin Dehydrogenase Nadp(+20-Beta-Hydroxysteroid DehydrogenaseAlcohol Dehydrogenase Nad(P+ Cbr1Nadph-Dependent Carbonyl Reductase 1Prostaglandin 9-KetoreductasePg-9-KrProstaglandin-E(2 9-ReductaseShort Chain Dehydrogenase/Reductase Family 21c Member 1 |
| Database Links | Reactome: R-HSA-2162123 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Carbonyl Reductase Nadph 1 protein15-Hydroxyprostaglandin Dehydrogenase Nadp(+ protein20-Beta-Hydroxysteroid Dehydrogenase proteinAlcohol Dehydrogenase Nad(P+ Cbr1 proteinNadph-Dependent Carbonyl Reductase 1 proteinProstaglandin 9-Ketoreductase proteinPg-9-Kr proteinProstaglandin-E(2 9-Reductase proteinShort Chain Dehydrogenase/Reductase Family 21c Member 1 proteinCBR1 proteinCBR proteinCRN proteinSDR21C1 protein |
Information sourced from Uniprot.org