Human CASQ1 protein (Recombinant) (N-His) (STJP008066)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CASQ1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CASQ1 |
| Gene ID | 844 |
| Uniprot ID | CASQ1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asn56-Asp396 |
Additional Info
| Post Translational Modifications | N-glycosylated. |
| Function | Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1.this plays an important role in triggering muscle contraction. Negatively regulates store-operated Ca(2+) entry (SOCE) activity. |
| Protein Name | Calsequestrin-1CalmitineCalsequestrin - Skeletal Muscle Isoform |
| Database Links | Reactome: R-HSA-2672351Reactome: R-HSA-5578775 |
| Cellular Localisation | Endoplasmic ReticulumSarcoplasmic ReticulumSarcoplasmic Reticulum LumenSarcoplasmic Reticulum MembranePeripheral Membrane ProteinLumenal SideMitochondrion MatrixThis Isoform Of Calsequestrin Occurs In The Sarcoplasmic Reticulum's Terminal Cisternae Luminal Spaces Of Fast Skeletal Muscle CellsPreferentially Forms Linear And Round Aggregates In The Endoplasmic Reticulum (Er) Of Resting CellsIn A Minority Of CellsHomogeneously Detected In The Er LumenColocalizes With Stim1 At Endoplasmic Reticulum In Response To A Depletion Of Intracellular Calcium |
| Alternative Protein Names | Calsequestrin-1 proteinCalmitine proteinCalsequestrin - Skeletal Muscle Isoform proteinCASQ1 proteinCASQ protein |
Information sourced from Uniprot.org