• Human BMPR-2 protein (Recombinant) (C-His) (STJP001410)
  • Human BMPR-2 protein (Recombinant) (C-His) (STJP001410)
  • Human BMPR-2 protein (Recombinant) (C-His) (STJP001410)
  • Human BMPR-2 protein (Recombinant) (C-His) (STJP001410)

Human BMPR-2 protein (Recombinant) (C-His) (STJP001410)

SKU:
STJP001410

£80.50 - £257.50
Current Stock:
Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 0.1 EU/Mu g of the protein by LAL method.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Human BMPR2 at 1 Mu g/mL (100 Mu L/well) can bind Human BMP2 with a linear range of 0.015-7.4 Mu g/ml.
Gene Symbol: BMPR2
Gene ID: 659
Uniprot ID: BMPR2_HUMAN
Immunogen: Recombinant Human BMPR-2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser27-Ile151) of human BMPR2 (Accession #NP_001195.2) fused with a 6×His tag at the C-terminus.
Immunogen Sequence: SQNQERLCAFKDPYQQDLGI GESRISHENGTILCSKGSTC YGLWEKSKGDINLVKQGCWS HIGDPQECHYEECVVTTTPP SIQNGTYRFCCCSTDLCNVN FTENFPPPDTTPLSPPHSFN RDETI
Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6.
Protein Name Bone Morphogenetic Protein Receptor Type-2
Bmp Type-2 Receptor
Bmpr-2
Bone Morphogenetic Protein Receptor Type Ii
Bmp Type Ii Receptor
Bmpr-Ii
Database Links Reactome: R-HSA-201451
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Bone Morphogenetic Protein Receptor Type-2 protein
Bmp Type-2 Receptor protein
Bmpr-2 protein
Bone Morphogenetic Protein Receptor Type Ii protein
Bmp Type Ii Receptor protein
Bmpr-Ii protein
BMPR2 protein
PPH1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance