Host: | HEK293 cells |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Recombinant-Human BMPR-2-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
Formulation: | Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
Immunoreactivity: | Measured by its binding ability in a functional ELISA. Immobilized Human BMPR2 at 1 Mu g/mL (100 Mu L/well) can bind Human BMP2 with a linear range of 0.015-7.4 Mu g/ml. |
Gene Symbol: | BMPR2 |
Gene ID: | 659 |
Uniprot ID: | BMPR2_HUMAN |
Immunogen: | Recombinant Human BMPR-2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser27-Ile151) of human BMPR2 (Accession #NP_001195.2) fused with a 6×His tag at the C-terminus. |
Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. |
Protein Name | Bone Morphogenetic Protein Receptor Type-2 Bmp Type-2 Receptor Bmpr-2 Bone Morphogenetic Protein Receptor Type Ii Bmp Type Ii Receptor Bmpr-Ii |
Database Links | Reactome: R-HSA-201451 |
Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein |
Alternative Protein Names | Bone Morphogenetic Protein Receptor Type-2 protein Bmp Type-2 Receptor protein Bmpr-2 protein Bone Morphogenetic Protein Receptor Type Ii protein Bmp Type Ii Receptor protein Bmpr-Ii protein BMPR2 protein PPH1 protein |
Information sourced from Uniprot.org