Human BMP-2 (Bone Morphogenetic Protein 2) Antibody Pair (STJAP00146)
General Information
| Short Description | This BMP-2 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Applications | ELISA |
| Host | Mouse/Mouse |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Monoclonal |
| Conjugation | Unconjugated/Biotin |
| Concentration | 0.5 mg/mL |
| Purification | Capture Purification: Protein A or G.Detection Purification: Protein A or G. |
| Formulation | Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4. |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | BMP2 |
| Gene ID | 650 |
| Uniprot ID | BMP2_HUMAN |
| Immunogen | Capture immunogen: Recombinant Human BMP-2 protein.Detection Immunogen: Recombinant Human BMP-2 protein. |
Additional Info
| Function | Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis. Induces cartilage and bone formation. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Also acts to promote expression of HAMP, via the interaction with its receptor BMPR1A/ALK3. Can also signal through non-canonical pathways such as ERK/MAP kinase signaling cascade that regulates osteoblast differentiation. Also stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A-ATF4 pathway by stimulating EIF2A phosphorylation which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling. |
| Protein Name | Bone Morphogenetic Protein 2Bmp-2Bone Morphogenetic Protein 2aBmp-2a |
| Database Links | Reactome: R-HSA-201451Reactome: R-HSA-2129379Reactome: R-HSA-8878166Reactome: R-HSA-8939902 |
| Cellular Localisation | Secreted |
| Alternative Antibody Pair Names | Bone Morphogenetic Protein 2 antibody pairBmp-2 antibody pairBone Morphogenetic Protein 2a antibody pairBmp-2a antibody pairBMP2 antibody pairBMP2A antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Human BMP-2 (Bone Morphogenetic Protein 2) Antibody Pair (STJAP00146)
This antibody pair detects human BMP-2 (Bone Morphogenetic Protein 2), corresponding to UniProt entry P12643. Reactivity is confirmed for human samples only.
The capture antibody is unconjugated and the detection antibody is biotinylated. Both are mouse monoclonal antibodies supplied at 0.5 mg/mL, formulated in PBS with 0.04% Proclin 300 and 50% glycerol at pH 7.4, and purified by Protein A or G.
This antibody pair is validated for ELISA. No other assay formats are listed in the product specifications.
Both antibodies were raised against recombinant human BMP-2 protein. No additional immunogen region details are provided in the current product specification.
Both the capture and detection antibodies should be stored at -20°C for long-term storage. Freeze-thaw cycles should be avoided to maintain reagent integrity.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.