| Function | Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity. Inhibits HNF1A-mediated transactivation of CYP1A2, CYP2E1 AND CYP3A11. |
| Protein Name | Class E Basic Helix-Loop-Helix Protein 41Bhlhe41Class B Basic Helix-Loop-Helix Protein 3Bhlhb3Differentially Expressed In Chondrocytes Protein 2Hdec2Enhancer-Of-Split And Hairy-Related Protein 1Sharp-1 |
| Database Links | Reactome: R-HSA-1368108Reactome: R-HSA-400253 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Class E Basic Helix-Loop-Helix Protein 41 proteinBhlhe41 proteinClass B Basic Helix-Loop-Helix Protein 3 proteinBhlhb3 proteinDifferentially Expressed In Chondrocytes Protein 2 proteinHdec2 proteinEnhancer-Of-Split And Hairy-Related Protein 1 proteinSharp-1 proteinBHLHE41 proteinBHLHB3 proteinDEC2 proteinSHARP1 protein |
Information sourced from Uniprot.org
