Human BCCIP protein (Recombinant) (N-His) (STJP008244)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human BCCIP-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | BCCIP |
| Gene ID | 56647 |
| Uniprot ID | BCCIP_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser67-Val314 |
Additional Info
| Function | During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole. Isoform 2/alpha is particularly important for the regulation of microtubule anchoring, microtubule stability, spindle architecture and spindle orientation, compared to isoform 1/beta. May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ). |
| Protein Name | Brca2 And Cdkn1a-Interacting ProteinP21- And Cdk-Associated Protein 1Protein Tok-1 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCentrioleSpindle PoleColocalizes With Brca2 In Discrete Nuclear FociIn InterphasePreferential Localizes To The Mother CentrioleRecruited To The Spindle Pole Matrix And Centrosome By Microtubules And Dynein/Dynactin ActivityIsoform 1: CytoplasmIsoform 1/Beta Tends To Be Less Abundant AtAnd Less Strongly Associated WithCentrosomes Than Isoform 2/AlphaIsoform 2: CytoplasmIsoform 2/Alpha Tends To Be More Abundant AtAnd More Strongly Associated WithCentrosomes Than Isoform 1/Beta |
| Alternative Protein Names | Brca2 And Cdkn1a-Interacting Protein proteinP21- And Cdk-Associated Protein 1 proteinProtein Tok-1 proteinBCCIP proteinTOK1 protein |
Information sourced from Uniprot.org