| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
< 0.1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: |
Measured by its binding ability in a functional ELISA. Immobilized Human B7-H2/ICOSLG at 1 Mu g/mL (100 Mu L/well) can bind Human ICOS/CD278 with a linear range of 2-14.8 ng/mL. |
| Gene Symbol: |
ICOSLG |
| Gene ID: |
23308 |
| Uniprot ID: |
ICOSL_HUMAN |
| Immunogen Region: |
Asp19-Ser258 |
| Immunogen: |
Recombinant Human B7-H2/ICOSLG/CD275 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asp19-Ser258) of human B7-H2/ICOSLG (Accession #NP_056074.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: |
DTQEKEVRAMVGSDVELSCA CPEGSRFDLNDVYVYWQTSE SKTVVTYHIPQNSSLENVDS RYRNRALMSPAGMLRGDFSL RLFNVTPQDEQKFHCLVLSQ SLGFQEVLSVEVTLHVAANF SVPVVSAPHSPSQDELTFTC TSINGYPRPNVYWINKTDNS LLDQALQNDTVFLNMRGLYD VVSVLRIARTPSVNIGCCIE NVLLQQNLTVGSQTGNDIGE RDKITENPVSTGEKNAATW |
| Function | Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion. Also induces B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. In endothelial cells, required for proper neutrophil transmigration in response to chemoattractants, such as CXCL8/IL8 or N-formyl-methionyl peptides (fMLP). |
| Protein Name | Icos LigandB7 Homolog 2B7-H2B7-Like Protein Gl50B7-Related Protein 1B7rp-1Cd Antigen Cd275 |
| Database Links | Reactome: R-HSA-388841 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Cell Membrane |
| Alternative Protein Names | Icos Ligand proteinB7 Homolog 2 proteinB7-H2 proteinB7-Like Protein Gl50 proteinB7-Related Protein 1 proteinB7rp-1 proteinCd Antigen Cd275 proteinICOSLG proteinB7H2 proteinB7RP1 proteinICOSL proteinKIAA0653 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
