Human AURKC protein (Recombinant) (N-His) (STJP006223)

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STJP006223
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Short Description :Recombinant-Human AURKC-N-His protein was developed from e.coli for the region N-His. For use in research applications.
Applications:ELISA/Immunogen/SDS-PAGE/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Dilution Range:Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation:Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol:AURKC
Gene ID:6795
Uniprot ID:AURKC_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Leu20-Gln277
Function Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Also plays a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.
Protein Name Aurora Kinase C
Aurora 3
Aurora/Ipl1-Related Kinase 3
Ark-3
Aurora-Related Kinase 3
Aurora/Ipl1/Eg2 Protein 2
Serine/Threonine-Protein Kinase 13
Serine/Threonine-Protein Kinase Aurora-C
Database Links
Cellular Localisation Nucleus
Chromosome
Centromere
Cytoplasm
Cytoskeleton
Spindle
Distributes In The Condensed Chromosomes During Prophase To Metaphase
After Entering Anaphase
There Is A Dissociation From Separated Chromosomes And A Redistribution To Midzone Microtubules
And Finally Remains In The Midbody During Cytokinesis
Alternative Protein Names Aurora Kinase C protein
Aurora 3 protein
Aurora/Ipl1-Related Kinase 3 protein
Ark-3 protein
Aurora-Related Kinase 3 protein
Aurora/Ipl1/Eg2 Protein 2 protein
Serine/Threonine-Protein Kinase 13 protein
Serine/Threonine-Protein Kinase Aurora-C protein
AURKC protein
AIE2 protein
AIK3 protein
AIRK3 protein
ARK3 protein
STK13 protein

Information sourced from Uniprot.org

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