| Function | Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Also plays a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'. |
| Protein Name | Aurora Kinase CAurora 3Aurora/Ipl1-Related Kinase 3Ark-3Aurora-Related Kinase 3Aurora/Ipl1/Eg2 Protein 2Serine/Threonine-Protein Kinase 13Serine/Threonine-Protein Kinase Aurora-C |
| Cellular Localisation | NucleusChromosomeCentromereCytoplasmCytoskeletonSpindleDistributes In The Condensed Chromosomes During Prophase To MetaphaseAfter Entering AnaphaseThere Is A Dissociation From Separated Chromosomes And A Redistribution To Midzone MicrotubulesAnd Finally Remains In The Midbody During Cytokinesis |
| Alternative Protein Names | Aurora Kinase C proteinAurora 3 proteinAurora/Ipl1-Related Kinase 3 proteinArk-3 proteinAurora-Related Kinase 3 proteinAurora/Ipl1/Eg2 Protein 2 proteinSerine/Threonine-Protein Kinase 13 proteinSerine/Threonine-Protein Kinase Aurora-C proteinAURKC proteinAIE2 proteinAIK3 proteinAIRK3 proteinARK3 proteinSTK13 protein |
Information sourced from Uniprot.org
