Human ATXN10 protein (Recombinant) (N-His) (STJP006124)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ATXN10-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ATXN10 |
| Gene ID | 25814 |
| Uniprot ID | ATX10_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Leu116-Ala302 |
Additional Info
| Post Translational Modifications | Polyubiquitinated. Phosphorylation at Ser-12 by AURKB promotes the association of ATXN10 with PLK1. Phosphorylation at Ser-77 and Thr-82 by PLK1 may play a role in the regulation of cytokinesis and may stimulate the proteasome-mediated degradation of ATXN10. |
| Function | May play a role in the regulation of cytokinesis. May play a role in signaling by stimulating protein glycosylation. Induces neuritogenesis by activating the Ras-MAP kinase pathway and is necessary for the survival of cerebellar neurons. Does not appear to play a major role in ciliogenesis. |
| Protein Name | Ataxin-10Brain Protein E46 HomologSpinocerebellar Ataxia Type 10 Protein |
| Database Links | |
| Cellular Localisation | CytoplasmPerinuclear RegionMidbodyCytoskeletonCilium Basal BodyMicrotubule Organizing CenterCentrosomeCentrioleLocalizes To The Midbody During Telophase |
| Alternative Protein Names | Ataxin-10 proteinBrain Protein E46 Homolog proteinSpinocerebellar Ataxia Type 10 Protein proteinATXN10 proteinSCA10 protein |
Information sourced from Uniprot.org