Human ATP11A protein (Recombinant) (N-His) (STJP015986)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ATP11A-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | ATP11A |
| Gene ID | 23250 |
| Uniprot ID | AT11A_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asp387-Lys860 |
Additional Info
| Post Translational Modifications | Proteolytically cleaved by CASP3. |
| Function | Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane. Does not show flippase activity toward phosphatidylcholine (PC). Contributes to the maintenance of membrane lipid asymmetry with a specific role in morphogenesis of muscle cells. In myoblasts, mediates PS enrichment at the inner leaflet of plasma membrane, triggering PIEZO1-dependent Ca2+ influx and Rho GTPases signal transduction, subsequently leading to the assembly of cortical actomyosin fibers and myotube formation. May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib. |
| Protein Name | Phospholipid-Transporting Atpase IhAtpase IsAtpase Class Vi Type 11aP4-Atpase Flippase Complex Alpha Subunit Atp11a |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-936837 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEarly EndosomeRecycling EndosomeEndoplasmic Reticulum MembraneEfficient Exit From The Endoplasmic Reticulum Requires The Presence Of Tmem30a |
| Alternative Protein Names | Phospholipid-Transporting Atpase Ih proteinAtpase Is proteinAtpase Class Vi Type 11a proteinP4-Atpase Flippase Complex Alpha Subunit Atp11a proteinATP11A proteinATPIH proteinATPIS proteinKIAA1021 protein |
Information sourced from Uniprot.org