Human ASPRV1 protein (Recombinant) (His-Tag) (STJP017876)

Name: Human ASPRV1 protein (Recombinant) (His-Tag) (STJP017876)
SKU: STJP017876
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostE.coli

ImmunogenHuman

STJP017876

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Short Description	Recombinant-Human ASPRV1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications	SDS-PAGE
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration	0.25 mg/mL
Formulation	Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% Glycerol, 1mM DTT
Storage Instruction	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.

Gene Symbol	ASPRV1
Gene ID	151516
Uniprot ID	APRV1_HUMAN
Accession Number	NP_690005
Immunogen	Human
Immunogen Region	191-326aa
Immunogen Sequence	SMGKGYY LKGKIGKVPV RFLVDSGAQV SVVHPNLWEE VTDGDLDTLQ PFENVVKVAN GAEMKILGVW DTAVSLGKLK LKAQFLVANA SAEEAIIGTD VLQDHNAILD FEHRTCTLKG KKFRLLPVGG SLEDEFDLE

Tissue Specificity	Expressed primarily in the granular layer of the epidermis and inner root sheath of hair follicles. In psoriatic skin, expressed throughout the stratum corneum. In ulcerated skin, expressed in the stratum granulosum of intact epidermis but almost absent from ulcerated regions. Expressed in differentiated areas of squamous cell carcinomas but not in undifferentiated tumors.
Post Translational Modifications	Undergoes autocleavage which is necessary for activation of the protein.
Function	Protease responsible for filaggrin processing, essential for the maintenance of a proper epidermis organization.
Protein Name	Retroviral-Like Aspartic Protease 1 Skin-Specific Retroviral-Like Aspartic Protease Saspase Skin Aspartic Protease Tpa-Inducible Aspartic Proteinase-Like Protein Taps
Database Links
Cellular Localisation	Membrane Single-Pass Membrane Protein
Alternative Protein Names	Retroviral-Like Aspartic Protease 1 protein Skin-Specific Retroviral-Like Aspartic Protease protein Saspase protein Skin Aspartic Protease protein Tpa-Inducible Aspartic Proteinase-Like Protein protein Taps protein ASPRV1 protein SASP protein

Information sourced from Uniprot.org