Human ARPC3 protein (Recombinant) (His-Tag) (STJP018142)

Name: Human ARPC3 protein (Recombinant) (His-Tag) (STJP018142)
SKU: STJP018142
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostE.coli

ImmunogenHuman

STJP018142

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Short Description	Recombinant-Human ARPC3-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications	SDS-PAGE
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration	0.5 mg/mL
Formulation	Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 30% Glycerol, 1mM DTT
Storage Instruction	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.

Gene Symbol	ARPC3
Gene ID	10094
Uniprot ID	ARPC3_HUMAN
Accession Number	NP_005710
Immunogen	Human
Immunogen Region	1-178aa
Immunogen Sequence	MPAYHSS LMDPDTKLIG NMALLPIRSQ FKGPAPRETK DTDIVDEAIY YFKANVFFKN YEIKNEADRT LIYITLYISE CLKKLQKCNS KSQGEKEMYT LGITNFPIPG EPGFPLNAIY AKPANKQEDE VMRAYLQQLR QETGLRLCEK VFDPQNDKPS KWWTCFVKRQ FMNKSLSGPG Q

Function	Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
Protein Name	Actin-Related Protein 2/3 Complex Subunit 3 Arp2/3 Complex 21 Kda Subunit P21-Arc
Database Links	Reactome: R-HSA-2029482 Reactome: R-HSA-3928662 Reactome: R-HSA-5663213 Reactome: R-HSA-8856828 Reactome: R-HSA-9664422
Cellular Localisation	Cytoplasm Cytoskeleton Cell Projection Nucleus
Alternative Protein Names	Actin-Related Protein 2/3 Complex Subunit 3 protein Arp2/3 Complex 21 Kda Subunit protein P21-Arc protein ARPC3 protein ARC21 protein

Information sourced from Uniprot.org