| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 29.4pg/mL |
| Detection Limit: | 78.1-5000pg/mL |
| Short Description : | This ARHGEF7 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates or other biological fluids. |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
| Gene Symbol: | ARHGEF7 |
| Gene ID: | 8874 |
| Uniprot ID: | ARHG7_HUMAN |
| Sample Type: | tissue homogenates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | Phosphorylated by PTK2/FAK1.this promotes interaction with RAC1. Phosphorylated on Ser-694 by CaMK1.enhancement of GEF activity and downstream activation of RAC1. |
| Function | Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. |
| Protein Name | Rho Guanine Nucleotide Exchange Factor 7Beta-PixCool-1Pak-Interacting Exchange Factor BetaP85 |
| Database Links | Reactome: R-HSA-182971Reactome: R-HSA-193648Reactome: R-HSA-3928664Reactome: R-HSA-416482Reactome: R-HSA-8980692Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013406Reactome: R-HSA-9013409Reactome: R-HSA-9013420Reactome: R-HSA-9013424Reactome: R-HSA-9619229 Q14155-1 |
| Cellular Localisation | Cell JunctionFocal AdhesionCell ProjectionRuffleCytoplasmCell CortexLamellipodiumDetected At Cell AdhesionsA Small Proportion Is Detected At Focal Adhesions |
| Alternative ELISA Names | Rho Guanine Nucleotide Exchange Factor 7 ELISA kitBeta-Pix ELISA kitCool-1 ELISA kitPak-Interacting Exchange Factor Beta ELISA kitP85 ELISA kitARHGEF7 ELISA kitCOOL1 ELISA kitKIAA0142 ELISA kitP85SPR ELISA kitPAK3BP ELISA kitPIXB ELISA kitNbla10314 ELISA kit |
| output |
Information sourced from Uniprot.org
