Human APOBEC3H protein (Recombinant) (N-His) (STJP016227)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human APOBEC3H-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | APOBEC3H |
| Gene ID | 164668 |
| Uniprot ID | ABC3H_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Val200 |
Additional Info
| Post Translational Modifications | (Microbial infection) Following infection by some HIV-1 strains, such as isolate BRU/LAI, can be ubiquitinated by a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex) hijacked by the HIV-1 Vif protein, leading to its degradation. Ubiquitination by the ECS complex is however less efficent compared to APOBEC3G or APOBEC3G. |
| Function | DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. The A3H-var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. |
| Protein Name | Dna Dc->Du-Editing Enzyme Apobec-3hApobec-Related Protein 10Arp-10Apolipoprotein B Mrna-Editing Enzyme Catalytic Polypeptide-Like 3hA3h |
| Database Links | Reactome: R-HSA-72200Reactome: R-HSA-75094 |
| Cellular Localisation | CytoplasmNucleusP-BodyHaplotype 1 Is Distributed In Both The Nucleus And CytoplasmWhereas Haplotype 2 Is Predominantly Cytoplasmic |
| Alternative Protein Names | Dna Dc->Du-Editing Enzyme Apobec-3h proteinApobec-Related Protein 10 proteinArp-10 proteinApolipoprotein B Mrna-Editing Enzyme Catalytic Polypeptide-Like 3h proteinA3h proteinAPOBEC3H protein |
Information sourced from Uniprot.org