| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
<0.1 EU/Mu g |
| Gene Symbol: |
APLP1 |
| Gene ID: |
333 |
| Uniprot ID: |
APLP1_HUMAN |
| Immunogen: |
Recombinant Human APLP-1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser39-Glu580) of human APLP1 (Accession #NP_005157.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: |
SLAGGSPGAAEAPGSAQVAG LCGRLTLHRDLRTGRWEPDP QRSRRCLRDPQRVLEYCRQM YPELQIARVEQATQAIPMER WCGGSRSGSCAHPHHQVVPF RCLPGEFVSEALLVPEGCRF LHQERMDQCESSTRRHQEAQ EACSSQGLILHGSGMLLPCG SDRFRGVEYVCCPPPGTPDP SGTAVGDPSTRSWPPGSRVE GAEDEEEEESFPQPVDDYFV EPPQAEEEEETVPPPSSHT |
| Post Translational Modifications | Proteolytically cleaved by caspases during neuronal apoptosis. Cleaved, in vitro, at Asp-620 by caspase-3. N- and O-glycosylated. O-glycosylation with core 1 or possibly core 8 glycans. Glycosylation on Ser-227 is the preferred site to Thr-228. |
| Function | May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding. Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis. |
| Protein Name | Amyloid Beta Precursor Like Protein 1Amyloid BetaA4 Precursor-Like Protein 1Amyloid-Like Protein 1AplpAplp-1 Cleaved Into - C30 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinC30: CytoplasmC-Terminally Processed In The Golgi Complex |
| Alternative Protein Names | Amyloid Beta Precursor Like Protein 1 proteinAmyloid Beta proteinA4 Precursor-Like Protein 1 proteinAmyloid-Like Protein 1 proteinAplp proteinAplp-1 Cleaved Into - C30 proteinAPLP1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
