| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: | Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human ANGPTL7 at 5 Mu g/mL (100 Mu L/well) can bind Recombinant Human LILRB4 with a linear range of 0.5-3.5 Mu g/mL. |
| Gene Symbol: | ANGPTL7 |
| Gene ID: | 10218 |
| Uniprot ID: | ANGL7_HUMAN |
| Immunogen: | Recombinant Human Angiopoietin-like 7/ANGPTL7 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln27-Pro346) of human Angiopoietin-like 7 (Accession #NP_066969.1) fused with a 6×His tag at the C-te |
| Immunogen Sequence: | QKLSKHKTPAQPQLKAANCC EEVKELKAQVANLSSLLSEL NKKQERDWVSVVMQVMELES NSKRMESRLTDAESKYSEMN NQIDIMQLQAAQTVTQTSAD AIYDCSSLYQKNYRISGVYK LPPDDFLGSPELEVFCDMET SGGGWTIIQRRKSGLVSFYR DWKQYKQGFGSIRGDFWLGN EHIHRLSRQPTRLRVEMEDW EGNLRYAEYSHFVLGNELNS YRLFLGNYTGNVGNDALQY |
| Tissue Specificity | Highly expressed in the cornea (at protein level). Expression is restricted to the stromal layer. Also detected at the junction between the corneal stromal layer and the conjuctiva. Not detected in the sclera. |
| Function | Has a role in the formation and organization of the extracellular matrix. In the eye, it functions as a mediator of dexamethasone-induced matrix deposition in the trabecular meshwork, the tissue responsible for the outflow of the ocular aqueous humor and for the maintenance of intraocular pressure. Is a negative regulator of angiogenesis in the cornea, and plays a major role in maintaining corneal avascularity and transparency. |
| Protein Name | Angiopoietin-Related Protein 7Angiopoietin-Like FactorAngiopoietin-Like Protein 7Cornea-Derived Transcript 6 Protein |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Angiopoietin-Related Protein 7 proteinAngiopoietin-Like Factor proteinAngiopoietin-Like Protein 7 proteinCornea-Derived Transcript 6 Protein proteinANGPTL7 proteinCDT6 proteinUNQ313 proteinPRO356 protein |
Information sourced from Uniprot.org