| Short Description : | Recombinant-Human Angiopoietin-4/ANG-4/ANGPT4 (23-503)-N-6His protein was developed in hek293 cells using the region Gln23-Ile503. For use in research applications. |
| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | <0.1 EU/Mu g |
| Gene Symbol: | ANGPT4 |
| Gene ID: | 51378 |
| Uniprot ID: | ANGP4_HUMAN |
| Immunogen: | Recombinant Human Angiopoietin-4/ANG-4/ANGPT4 (23-503) Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln23-Ile503) of human ANG-4/ANGPT4 (Accession #NP_057069.1) fused with and a 6×His tag at th |
| Immunogen Region: | Gln23-Ile503 |
| Immunogen Sequence: | RGQRGKNRGCVLTAIHLNVT DLGLGYETKEELIFRYCSGS CDAAETTYDKILKNLSRNRR LVSDKVGQACCRPIAFDDDL SFLDDNLVYHILRKHSAKRC GCI |
| Tissue Specificity | Highly expressed in the lung with much lower levels found in other tissues. |
| Function | Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis. |
| Protein Name | Angiopoietin-4Ang-4Angiopoietin-3Ang-3 |
| Database Links | Reactome: R-HSA-210993 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Angiopoietin-4 proteinAng-4 proteinAngiopoietin-3 proteinAng-3 proteinANGPT4 proteinANG3 proteinANG4 protein |
Information sourced from Uniprot.org
