Human Amnionless protein (Recombinant) (His-Tag) (STJP017973)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Amnionless-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | AMN |
| Gene ID | 81693 |
| Uniprot ID | AMNLS_HUMAN |
| Accession Number | NP_112205 |
| Immunogen | Human |
| Immunogen Region | 20-357aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Detected in proximal tubules in the kidney cortex (at protein level). Long isoforms are highly expressed in small intestine, colon and kidney (renal proximal tubule epithelial cells). Shorter isoforms are detected at lower levels in testis, thymus and peripheral blood leukocytes. |
| Post Translational Modifications | N-glycosylated. A soluble form arises by proteolytic removal of the membrane anchor. |
| Function | Membrane-bound component of the endocytic receptor formed by AMN and CUBN. Required for normal CUBN glycosylation and trafficking to the cell surface. The complex formed by AMN and CUBN is required for efficient absorption of vitamin B12. Required for normal CUBN-mediated protein transport in the kidney (Probable). |
| Protein Name | Protein Amnionless Cleaved Into - Soluble Protein Amnionless |
| Database Links | Reactome: R-HSA-3359462Reactome: R-HSA-3359463Reactome: R-HSA-8964011Reactome: R-HSA-9758881 |
| Cellular Localisation | Isoform 1: Apical Cell MembraneSingle-Pass Type I Membrane ProteinCell MembraneEndosome MembraneMembraneCoated PitSoluble Protein Amnionless: Secreted |
| Alternative Protein Names | Protein Amnionless Cleaved Into - Soluble Protein Amnionless proteinAMN proteinUNQ513 proteinPRO1028 protein |
Information sourced from Uniprot.org