Human alpha-Parvin protein (Recombinant) (His-Tag) (STJP017872)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human alpha-Parvin-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PARVA |
| Gene ID | 55742 |
| Uniprot ID | PARVA_HUMAN |
| Accession Number | NP_060692 |
| Immunogen | Human |
| Immunogen Region | 1-372aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver. |
| Function | Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development. Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration. Within the IPP (ILK-PINCH-PARVIN) complex, binds to F-actin, promoting F-actin bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration. |
| Protein Name | Alpha-ParvinActopaxinCh-IlkbpCalponin-Like Integrin-Linked Kinase-Binding ProteinMatrix-Remodeling-Associated Protein 2 |
| Database Links | Reactome: R-HSA-446343Reactome: R-HSA-446353Reactome: R-HSA-446388 |
| Cellular Localisation | Cell JunctionFocal AdhesionCell MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmCytoskeletonMyofibrilSarcomereZ Line |
| Alternative Protein Names | Alpha-Parvin proteinActopaxin proteinCh-Ilkbp proteinCalponin-Like Integrin-Linked Kinase-Binding Protein proteinMatrix-Remodeling-Associated Protein 2 proteinPARVA proteinMXRA2 protein |
Information sourced from Uniprot.org