Human ALKBH4 protein (Recombinant) (N-His) (STJP008206)

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STJP008206
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ALKBH4-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ALKBH4
Gene ID: 54784
Uniprot ID: ALKB4_HUMAN
Immunogen Region: Thr8-Val302
Immunogen: Homo sapiens (Human)
Function Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes. Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing.
Protein Name Alpha-Ketoglutarate-Dependent Dioxygenase Alkb Homolog 4
Alkylated Dna Repair Protein Alkb Homolog 4
Dna N6-Methyl Adenine Demethylase Alkbh4
Lysine-Specific Demethylase Alkbh4
Cellular Localisation Cytoplasm
Nucleus
Nucleolus
Midbody
Associates With The Contractile Ring And Midbody
Alternative Protein Names Alpha-Ketoglutarate-Dependent Dioxygenase Alkb Homolog 4 protein
Alkylated Dna Repair Protein Alkb Homolog 4 protein
Dna N6-Methyl Adenine Demethylase Alkbh4 protein
Lysine-Specific Demethylase Alkbh4 protein
ALKBH4 protein
ABH4 protein

Information sourced from Uniprot.org

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