Human Aldo-keto Reductase 1C1/AKR1C1 protein (Recombinant) (His-Tag) (STJP016637)

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STJP016637
€150.60 - €779.40
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Host: E.coli
Applications: SDS-PAGE/Enzyme Activity
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human Aldo-keto Reductase 1C1/AKR1C1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% Glycerol
Concentration: 0.5 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Immunoreactivity: Specific activity is > 500pmol/min/ug, and is defined as the amount of enzyme that catalyze the oxidation of 1.0pmole 1-Acenaphthenol in the presence of NADP per minute at pH 8.8 at 25C.
Gene Symbol: AKR1C1
Gene ID: 1645
Uniprot ID: AK1C1_HUMAN
Immunogen Region: 1-323aa
Accession Number: NP_001344
Immunogen: Human
Immunogen Sequence: MGSSHHHHHH SSGLVPRGSH MDSKYQCVKL NDGHFMPVLG FGTYAPAEVP KSKALEATKL AIEAGFRHID SAHLYNNEEQ VGLAIRSKIA DGSVKREDIF YTSKLWCNSH RPELVRPALE RSLKNLQLDY VDLYLIHFPV SVKPGEEVIP KDENGKILFD TVDLCATWEA VEKCKDAGLA KSIGVSNFNR RQLEMILNKP GLKYKPVCNQ VECHPYFNQR KLLDFCKS
Tissue Specificity Expressed in all tissues tested including liver, prostate, testis, adrenal gland, brain, uterus, mammary gland and keratinocytes. Highest levels found in liver, mammary gland and brain.
Function Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH. Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens. May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate. Displays affinity for bile acids.
Protein Name Aldo-Keto Reductase Family 1 Member C1
20-Alpha-Hydroxysteroid Dehydrogenase
20-Alpha-Hsd
Chlordecone Reductase Homolog Hakrc
Dihydrodiol Dehydrogenase 1
Dd1
High-Affinity Hepatic Bile Acid-Binding Protein
Hbab
Database Links Reactome: R-HSA-193368
Reactome: R-HSA-193775
Reactome: R-HSA-193807
Reactome: R-HSA-975634
Reactome: R-HSA-9757110
Cellular Localisation Cytoplasm
Cytosol
Alternative Protein Names Aldo-Keto Reductase Family 1 Member C1 protein
20-Alpha-Hydroxysteroid Dehydrogenase protein
20-Alpha-Hsd protein
Chlordecone Reductase Homolog Hakrc protein
Dihydrodiol Dehydrogenase 1 protein
Dd1 protein
High-Affinity Hepatic Bile Acid-Binding Protein protein
Hbab protein
AKR1C1 protein
DDH protein
DDH1 protein

Information sourced from Uniprot.org

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