Human ALDH1A1 protein (Recombinant) (N-His) (STJP003464)

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STJP003464
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ALDH1A1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ALDH1A1
Gene ID: 216
Uniprot ID: AL1A1_HUMAN
Immunogen Region: Met1-Ser501
Immunogen: Homo sapiens (Human)
Post Translational Modifications The N-terminus is blocked most probably by acetylation.
Function Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid. Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid. This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic. Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification. Functions also downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins. Has also an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission.
Protein Name Aldehyde Dehydrogenase 1a1
3-Deoxyglucosone Dehydrogenase
Aldh-E1
Alhdii
Aldehyde Dehydrogenase Family 1 Member A1
Aldehyde Dehydrogenase - Cytosolic
Retinal Dehydrogenase 1
Raldh 1
Raldh1
Database Links Reactome: R-HSA-5365859
Reactome: R-HSA-70350
Reactome: R-HSA-71384
Cellular Localisation Cytoplasm
Cytosol
Cell Projection
Axon
Alternative Protein Names Aldehyde Dehydrogenase 1a1 protein
3-Deoxyglucosone Dehydrogenase protein
Aldh-E1 protein
Alhdii protein
Aldehyde Dehydrogenase Family 1 Member A1 protein
Aldehyde Dehydrogenase - Cytosolic protein
Retinal Dehydrogenase 1 protein
Raldh 1 protein
Raldh1 protein
ALDH1A1 protein
ALDC protein
ALDH1 protein
PUMB1 protein

Information sourced from Uniprot.org

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