Human ADPRS protein (Recombinant) (N-His) (STJP016183)

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STJP016183
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Short Description :Recombinant-Human ADPRS-N-His protein was developed from e.coli for the region N-His. For use in research applications.
Applications:ELISA/Immunogen/SDS-PAGE/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Dilution Range:Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation:Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin:Please contact us for further information.
Gene Symbol:ADPRS
Gene ID:54936
Uniprot ID:ADPRS_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Ser19-Ser363
Function ADP-ribosylhydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on serine and threonine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose. Specifically acts as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Does not hydrolyze ADP-ribosyl-arginine, -cysteine, -diphthamide, or -asparagine bonds. Also able to degrade protein free poly(ADP-ribose), which is synthesized in response to DNA damage: free poly(ADP-ribose) acts as a potent cell death signal and its degradation by ADPRHL2 protects cells from poly(ADP-ribose)-dependent cell death, a process named parthanatos. Also hydrolyzes free poly(ADP-ribose) in mitochondria. Specifically digests O-acetyl-ADP-D-ribose, a product of deacetylation reactions catalyzed by sirtuins. Specifically degrades 1''-O-acetyl-ADP-D-ribose isomer, rather than 2''-O-acetyl-ADP-D-ribose or 3''-O-acetyl-ADP-D-ribose isomers.
Protein Name Adp-Ribosylhydrolase Arh3
Adp-Ribose Glycohydrolase Arh3
Adp-Ribosylhydrolase 3
O-Acetyl-Adp-Ribose Deacetylase Arh3
Poly(Adp-Ribose Glycohydrolase Arh3
Protein Adp-Ribosylarginine Hydrolase-Like Protein 2
Protein Adp-Ribosylserine Hydrolase
Database Links Reactome: R-HSA-110362
Cellular Localisation Nucleus
Cytoplasm
Chromosome
Mitochondrion Matrix
Recruited To Dna Lesion Regions Following Dna Damage
Adp-D-Ribose-Recognition Is Required For Recruitment To Dna Damage Sites
Alternative Protein Names Adp-Ribosylhydrolase Arh3 protein
Adp-Ribose Glycohydrolase Arh3 protein
Adp-Ribosylhydrolase 3 protein
O-Acetyl-Adp-Ribose Deacetylase Arh3 protein
Poly(Adp-Ribose Glycohydrolase Arh3 protein
Protein Adp-Ribosylarginine Hydrolase-Like Protein 2 protein
Protein Adp-Ribosylserine Hydrolase protein
ADPRS protein
ADPRHL2 protein
ARH3 protein

Information sourced from Uniprot.org

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