Human ACOT8 protein (Recombinant) (N-His) (STJP010628)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ACOT8-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ACOT8 |
| Gene ID | 10005 |
| Uniprot ID | ACOT8_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gly21-Leu319 |
Additional Info
| Function | Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Displays no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs. Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains. Moreover, it catalyzes the hydrolysis of CoA esters of bile acids, such as choloyl-CoA and chenodeoxycholoyl-CoA and competes with bile acid CoA:amino acid N-acyltransferase (BAAT). Is also able to hydrolyze CoA esters of dicarboxylic acids. It is involved in the metabolic regulation of peroxisome proliferation. (Microbial infection) May mediate Nef-induced down-regulation of CD4 cell-surface expression. |
| Protein Name | Acyl-Coenzyme A Thioesterase 8Acyl-Coa Thioesterase 8 Choloyl-Coenzyme A ThioesteraseHiv-Nef-Associated Acyl-Coa ThioesterasePeroxisomal Acyl-Coa Thioesterase 2Pte-2Peroxisomal Acyl-Coenzyme A Thioester Hydrolase 1Pte-1Peroxisomal Long-Chain Acyl-Coa Thioesterase 1Thioesterase IiHacte-IiiHacteiiiHte |
| Database Links | Reactome: R-HSA-193368Reactome: R-HSA-2046106Reactome: R-HSA-389887Reactome: R-HSA-390247Reactome: R-HSA-9033241 |
| Cellular Localisation | Peroxisome MatrixPredominantly Localized In The Peroxisome But A Localization To The Cytosol Cannot Be Excluded |
| Alternative Protein Names | Acyl-Coenzyme A Thioesterase 8 proteinAcyl-Coa Thioesterase 8 proteinCholoyl-Coenzyme A Thioesterase proteinHiv-Nef-Associated Acyl-Coa Thioesterase proteinPeroxisomal Acyl-Coa Thioesterase 2 proteinPte-2 proteinPeroxisomal Acyl-Coenzyme A Thioester Hydrolase 1 proteinPte-1 proteinPeroxisomal Long-Chain Acyl-Coa Thioesterase 1 proteinThioesterase Ii proteinHacte-Iii proteinHacteiii proteinHte proteinACOT8 proteinACTEIII proteinPTE1 protein |
Information sourced from Uniprot.org