||Human ACE2 Protein (STJP000026) produced in human. Suitable for elisa.
||FOR RESEARCH USE ONLY (RUO).
||Store the lyophilized protein at-20°C to-80°C for long term.After reconstitution, the protein solution is stable at-20°C for 3 months, at 2-8°C for up to 1 week.
||Source using HEK293 cells. Less than 1.0 EU/Mu g of the protein by LAL method.
| Post Translational Modifications || N-glycosylation on Asn-90 may limit SARS infectivity. Proteolytic cleavage by ADAM17 generates a secreted form. Also cleaved by serine proteases: TMPRSS2, TMPRSS11D and HPN/TMPRSS1. |
| Function || Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis. Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II. Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin. Also cleaves other biological peptides, such as apelins (apelin-13, Pyr1apelin-13, apelin-17, apelin-36), casomorphins (beta-casomorphin-7, neocasomorphin) and dynorphin A with high efficiency. In addition, ACE2 C-terminus is homologous to collectrin and is responsible for the trafficking of the neutral amino acid transporter SL6A19 to the plasma membrane of gut epithelial cells via direct interaction, regulating its expression on the cell surface and its catalytic activity. Isoform 2: Non-functional as a carboxypeptidase. (Microbial infection) Acts as a receptor for human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63. Isoform 2: (Microbial infection) Non-functional as a receptor for human coronavirus SARS-CoV-2. |
| Protein Name || Angiotensin-Converting Enzyme 2Angiotensin-Converting Enzyme HomologAcehAngiotensin-Converting Enzyme-Related CarboxypeptidaseAce-Related CarboxypeptidaseMetalloprotease Mprot15 Cleaved Into - Processed Angiotensin-Converting Enzyme 2 |
| Database Links || Reactome: R-HSA-2022377Reactome: R-HSA-9678110Reactome: R-HSA-9679191Reactome: R-HSA-9694614 |
| Cellular Localisation || Processed Angiotensin-Converting Enzyme 2: SecretedCell MembraneSingle-Pass Type I Membrane ProteinCytoplasmDetected In Both Cell Membrane And Cytoplasm In Neurons |
| Alternative Protein Names || Angiotensin-Converting Enzyme 2 proteinAngiotensin-Converting Enzyme Homolog proteinAceh proteinAngiotensin-Converting Enzyme-Related Carboxypeptidase proteinAce-Related Carboxypeptidase proteinMetalloprotease Mprot15 Cleaved Into - Processed Angiotensin-Converting Enzyme 2 proteinACE2 proteinUNQ868 proteinPRO1885 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance