• Human ACE2 Protein (STJP000026)
  • Human ACE2 Protein (STJP000026)

Human ACE2 Protein (STJP000026)

SKU:
STJP000026

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Host: Human
Applications: ELISA
Short Description: Human ACE2 Protein (STJP000026) produced in human. Suitable for elisa.
Note: FOR RESEARCH USE ONLY (RUO).
Storage Instruction: Store the lyophilized protein at-20°C to-80°C for long term.After reconstitution, the protein solution is stable at-20°C for 3 months, at 2-8°C for up to 1 week.
Isotype: IgG
Uniprot ID: ACE2_HUMAN
Gene ID: 59272
Gene Symbol: ACE2
Immunogen: Source using HEK293 cells. Less than 1.0 EU/Mu g of the protein by LAL method.
Post Translational Modifications N-glycosylation on Asn-90 may limit SARS infectivity. Proteolytic cleavage by ADAM17 generates a secreted form. Also cleaved by serine proteases: TMPRSS2, TMPRSS11D and HPN/TMPRSS1.
Function Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis. Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II. Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin. Also cleaves other biological peptides, such as apelins (apelin-13, Pyr1apelin-13, apelin-17, apelin-36), casomorphins (beta-casomorphin-7, neocasomorphin) and dynorphin A with high efficiency. In addition, ACE2 C-terminus is homologous to collectrin and is responsible for the trafficking of the neutral amino acid transporter SL6A19 to the plasma membrane of gut epithelial cells via direct interaction, regulating its expression on the cell surface and its catalytic activity. Isoform 2: Non-functional as a carboxypeptidase. (Microbial infection) Acts as a receptor for human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63. Isoform 2: (Microbial infection) Non-functional as a receptor for human coronavirus SARS-CoV-2.
Protein Name Angiotensin-Converting Enzyme 2
Angiotensin-Converting Enzyme Homolog
Aceh
Angiotensin-Converting Enzyme-Related Carboxypeptidase
Ace-Related Carboxypeptidase
Metalloprotease Mprot15 Cleaved Into - Processed Angiotensin-Converting Enzyme 2
Database Links Reactome: R-HSA-2022377
Reactome: R-HSA-9678110
Reactome: R-HSA-9679191
Reactome: R-HSA-9694614
Cellular Localisation Processed Angiotensin-Converting Enzyme 2: Secreted
Cell Membrane
Single-Pass Type I Membrane Protein
Cytoplasm
Detected In Both Cell Membrane And Cytoplasm In Neurons
Alternative Protein Names Angiotensin-Converting Enzyme 2 protein
Angiotensin-Converting Enzyme Homolog protein
Aceh protein
Angiotensin-Converting Enzyme-Related Carboxypeptidase protein
Ace-Related Carboxypeptidase protein
Metalloprotease Mprot15 Cleaved Into - Processed Angiotensin-Converting Enzyme 2 protein
ACE2 protein
UNQ868 protein
PRO1885 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance