Human 4E-BP3/EIF4EBP3 protein (Recombinant) (His-Tag) (STJP018868)

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STJP018868
£134.50 - £738.50
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human 4E-BP3/EIF4EBP3-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% Glycerol, 1mM DTT
Concentration: 0.25 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: EIF4EBP3
Gene ID: 8637
Uniprot ID: 4EBP3_HUMAN
Immunogen Region: 1-100aa
Accession Number: NP_003723
Immunogen: Human
Immunogen Sequence: MGSSHHHHHH SSGLVPRGSH MGSMSTSTSC PIPGGRDQLP DCYSTTPGGT LYATTPGGTR IIYDRKFLLE CKNSPIARTP PCCLPQIPGV TTPPTAPLSK LEELKEQETE EEIPDDAQFE MDI
Tissue Specificity Expression is highest in skeletal muscle, heart, kidney, and pancreas, whereas there is very little expression in brain and thymus.
Post Translational Modifications Phosphorylated.
Function Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: the hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repression of translation. In contrast, the hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Inhibits EIF4E-mediated mRNA nuclear export.
Protein Name Eukaryotic Translation Initiation Factor 4e-Binding Protein 3
4e-Bp3
Eif4e-Binding Protein 3
Database Links
Cellular Localisation Cytoplasm
Nucleus
Alternative Protein Names Eukaryotic Translation Initiation Factor 4e-Binding Protein 3 protein
4e-Bp3 protein
Eif4e-Binding Protein 3 protein
EIF4EBP3 protein

Information sourced from Uniprot.org

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