Human CPEB3/CPE-BP3 protein (Recombinant) (N-His) (STJP015096)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CPEB3/CPE-BP3-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-145°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | CPEB3 |
| Gene ID | 22849 |
| Uniprot ID | CPEB3_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser440-Arg673 |
Additional Info
| Function | Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator. In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure. Required for the consolidation and maintenance of hippocampal-based long term memory. In the basal state, binds to the mRNA 3'-UTR of the glutamate receptors GRIA2/GLUR2 mRNA and negatively regulates their translation. Also represses the translation of DLG4, GRIN1, GRIN2A and GRIN2B. When activated, acts as a translational activator of GRIA1 and GRIA2. In the basal state, suppresses SUMO2 translation but activates it following neuronal stimulation. Binds to the 3'-UTR of TRPV1 mRNA and represses TRPV1 translation which is required to maintain normal thermoception. Binds actin mRNA, leading to actin translational repression in the basal state and to translational activation following neuronal stimulation. Negatively regulates target mRNA levels by binding to TOB1 which recruits CNOT7/CAF1 to a ternary complex and this leads to target mRNA deadenylation and decay. In addition to its role in translation, binds to and inhibits the transcriptional activation activity of STAT5B without affecting its dimerization or DNA-binding activity. This, in turn, represses transcription of the STAT5B target gene EGFR which has been shown to play a role in enhancing learning and memory performance. In contrast to CPEB1, CPEB2 and CPEB4, not required for cell cycle progression. |
| Protein Name | Cytoplasmic Polyadenylation Element-Binding Protein 3Cpe-Bp3Cpe-Binding Protein 3Hcpeb-3 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusSynapseCell ProjectionDendritePostsynaptic DensityPredominantly Cytoplasmic In Unstimulated Neurons But Translocates To The Nucleus Following Neuronal StimulationNuclear Import Is Mediated By Importin Ipo5 |
| Alternative Protein Names | Cytoplasmic Polyadenylation Element-Binding Protein 3 proteinCpe-Bp3 proteinCpe-Binding Protein 3 proteinHcpeb-3 proteinCPEB3 proteinKIAA0940 protein |
Information sourced from Uniprot.org