| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Glucose Transporter GLUT1 Blocking Peptide is synthetically produced from the 478-492 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
SLC2A1 |
| Gene ID: |
6513 |
| Uniprot ID: |
GTR1_HUMAN |
| Immunogen Region: |
478-492 |
| Immunogen: |
Synthetic peptide conjugated to KLH, corresponding to amino acids 478-492 of Human Glucose Transporter GLUT1. Peptide was covalently modified. Sequence: PEELFHPLGADSQV |
| Tissue Specificity | Detected in erythrocytes (at protein level). Expressed at variable levels in many human tissues. |
| Post Translational Modifications | Phosphorylation at Ser-226 by PKC promotes glucose uptake by increasing cell membrane localization. |
| Function | Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity.can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain. In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors. Required for mesendoderm differentiation. |
| Peptide Name | Solute Carrier Family 2 - Facilitated Glucose Transporter Member 1Glucose Transporter Type 1 - Erythrocyte/BrainGlut-1Hepg2 Glucose Transporter |
| Database Links | Reactome: R-HSA-189200Reactome: R-HSA-196836Reactome: R-HSA-422356Reactome: R-HSA-5619043Reactome: R-HSA-5653890 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinMelanosomePhotoreceptor Inner SegmentLocalizes Primarily At The Cell SurfaceIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv |
| Alternative Peptide Names | Solute Carrier Family 2 - Facilitated Glucose Transporter Member 1 proteinGlucose Transporter Type 1 - Erythrocyte/Brain proteinGlut-1 proteinHepg2 Glucose Transporter proteinSLC2A1 proteinGLUT1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
