| Applications: | WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | FNDC5 Positive Control for STJ501505 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: | WB: 1:500 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | Fndc5 |
| Gene ID: | 384061 |
| Uniprot ID: | FNDC5_MOUSE |
| Specificity: | This is positive control is recommended for use in combination with FNDC5 antibody STJ501505. |
| Tissue Specificity | In adult, it is highly expressed in skeletal muscle, heart and brain. |
| Post Translational Modifications | The extracellular domain is cleaved and released from the cell membrane. N-Glycosylated. |
| Function | Irisin: Mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA. |
| Peptide Name | Fibronectin Type Iii Domain-Containing Protein 5 Fibronectin Type Iii Repeat-Containing Protein 2 Peroxisomal Protein Pep Cleaved Into - Irisin |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Peroxisome Membrane Secreted Imported In Peroxisomes Through The Pex5 Receptor Pathway Irisin: Secreted Detected In The Blood Of Individuals Subjected To Endurance Exercise |
| Alternative Peptide Names | Fibronectin Type Iii Domain-Containing Protein 5 protein Fibronectin Type Iii Repeat-Containing Protein 2 protein Peroxisomal Protein protein Pep Cleaved Into - Irisin protein Fndc5 protein Frcp2 protein Pep protein |
Information sourced from Uniprot.org