| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
DCC Positive Control for STJ500739 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: |
WB: 1:500 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
DCC |
| Gene ID: |
1630 |
| Uniprot ID: |
DCC_HUMAN |
| Specificity: |
This is positive control is recommended for use in combination with DCC antibody STJ500739. |
| Tissue Specificity | Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells. |
| Post Translational Modifications | Ubiquitinated.mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation. |
| Function | Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. |
| Peptide Name | Netrin Receptor DccColorectal Cancer SuppressorImmunoglobulin Superfamily Dcc Subclass Member 1Tumor Suppressor Protein Dcc |
| Database Links | Reactome: R-HSA-373752Reactome: R-HSA-376172Reactome: R-HSA-418885Reactome: R-HSA-418886Reactome: R-HSA-418889Reactome: R-HSA-418890Reactome: R-HSA-428542 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Peptide Names | Netrin Receptor Dcc proteinColorectal Cancer Suppressor proteinImmunoglobulin Superfamily Dcc Subclass Member 1 proteinTumor Suppressor Protein Dcc proteinDCC proteinIGDCC1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
