Trial size APOE antibodies available in the Antibody Validation Project

Introduction:

Apolipoprotein E(APOE) is a major cholesterol carrier supporting lipid transport and injury repair in the brain. The polymorphic alleles of the gene that synthesises APOE are the main genetic reasons for Alzheimer's disease and some mutations of it may cause liver cancer. We provide a number of trial sized antibodies, which are suitable for APOE research purposes, and to help you make the right decision and find the best suited antibody for you, please find the answers to some of the key topics regarding APOE that we have provided in the links below.

• What is APOE?
• Where is APOE found?
• What role does APOE play in disease?
• APOE antibodies in the Antibody Validation project
• Customer reviewed APOE antibodies
• Other APOE antibodies available in the Antibody Validation Project
• Popular APOE antibodies not currently in the Antibody Validation Project
• How does the Antibody Validation Project work?

What is APOE?

APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma.

Where is APOE found?

APOE is mainly found in the vesicles of the cells and is predicted to be secreted, and is present in many tissues, enhanced in the adrenal gland and liver. The synthesised protein can be found expressed in the renal tubules, Leydig cells and subset of neurons.

What role does APOE play in disease?

Although the gene product is not prognostic, traces of the gene have been found in many cancers, particularly liver cancer

Apart from that, the APOE gene is classified as a risk gene for Alzheimer's disease. Because the APOE gene has three common forms, the first one is the rarest and appears to reduce the risk of the disease, the second is a little more common and increases the risk and the third is the most common and doesn't affect the risk of the disease.

APOE antibodies in the Antibody Validation project

St John's Laboratory offers a variety of trial size primary antibodies which target APOE, which are available to try through the Antibody Validation Project. Below we highlight those which have already been reviewed, as well as others which are available to try.

Customer reviewed APOE antibodies

Model	Name	Host	Clonality	Rating	Application Tested
STJ91638	Anti-ApoE antibody	Rabbit	Polyclonal	4	ICC
STJ91638	Anti-ApoE antibody	Rabbit	Polyclonal	4	WB

Other APOE antibodies available in the Antibody Validation Project

Model	Name	Host	Clonality	Recommended Applications
STJ150123	Human APOE ELISA Kit			ELISA
STJ150264	Mouse APOE ELISA Kit			ELISA
STJ91639	Anti-ApoE antibody	Rabbit	Polyclonal	WB,ELISA
STJ97839	Anti-ApoE antibody	Mouse	Monoclonal	WB,IHC,FC,ELISA

Popular APOE antibodies not currently in the Antibody Validation Project

Model	Name	Host	Clonality	Recommended Applications
STJ114931	Anti-ApoE Antibody	Rabbit	Polyclonal	WB,IHC
STJ118772	Anti-APOE Antibody	Rabbit	Polyclonal	WB,IF
STJ29789	Anti-ApoE Antibody	Rabbit	Polyclonal	IHC,IF

How does the Antibody Validation Project work?

In order to help our customers with their choice of antibody with low risk, we offer one of the largest ranges of primary antibodies with trial size options available.

The Antibody Validation Project works like this.
1. Order your trial size antibody online.
2. Explore its suitability.
3. Return your results by posting them on the product page.
4. Receive a sample refund.

Find out more here.