Axin 2 Positive Control peptide (STJ503707)
SPECIFICATIONS
General Information
| Short Description | Axin 2 Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Applications | WB |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | WB: 1:500 |
| Formulation | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | AXIN2 |
| Gene ID | 8313 |
| Uniprot ID | AXIN2_HUMAN |
Additional Info
| Tissue Specificity | Expressed in brain and lymphoblast. |
| Post Translational Modifications | Probably phosphorylated by GSK3B and dephosphorylated by PP2A. ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination and subsequent activation of the Wnt signaling pathway. Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription. |
| Function | Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B. |
| Peptide Name | Axin-2Axin-Like ProteinAxilAxis Inhibition Protein 2Conductin |
| Database Links | Reactome: R-HSA-201681Reactome: R-HSA-4411364Reactome: R-HSA-4641257Reactome: R-HSA-5689880 |
| Cellular Localisation | Cytoplasm |
| Alternative Peptide Names | Axin-2 proteinAxin-Like Protein proteinAxil proteinAxis Inhibition Protein 2 proteinConductin proteinAXIN2 protein |
Information sourced from Uniprot.org