Anti-ZRANB1 antibody (255-305 aa) (STJ195355)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human ZRAN1 at the amino acid range 255-305
General Information
| Short Description | Rabbit polyclonal anti-Ubiquitin thioesterase ZRANB1 (255-305 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ZRANB1 |
| Gene ID | 54764 |
| Uniprot ID | ZRAN1_HUMAN |
| Immunogen | Synthesized peptide derived from the human ZRAN1 at the amino acid range 255-305 |
| Immunogen Region | 255-305 aa |
| Specificity | This antibody detects endogenous levels of ZRAN1 at Human/Mouse |
Additional Info
| Function | Ubiquitin thioesterase, which specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Acts as a regulator of autophagy by mediating deubiquitination of PIK3C3/VPS34, thereby promoting autophagosome maturation. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. |
| Protein Name | Ubiquitin Thioesterase Zranb1Traf-Binding Domain-Containing ProteinHtrabidZinc Finger Ran-Binding Domain-Containing Protein 1 |
| Database Links | Reactome: R-HSA-195253Reactome: R-HSA-5689896 |
| Cellular Localisation | CytoplasmNucleusEnriched In Punctate Localization In The Cytoplasm |
| Alternative Antibody Names | Anti-Ubiquitin Thioesterase Zranb1 antibodyAnti-Traf-Binding Domain-Containing Protein antibodyAnti-Htrabid antibodyAnti-Zinc Finger Ran-Binding Domain-Containing Protein 1 antibodyAnti-ZRANB1 antibodyAnti-TRABID antibody |
Information sourced from Uniprot.org