| Post Translational Modifications | Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida. Proteolytically cleaved in the N-terminal part by the metalloendopeptidase ASTL exocytosed from cortical granules after fertilization, yielding a N-terminal peptide of about 30 kDa which remains covalently attached to the C-terminal peptide via disulfide bond(s). This cleavage may play an important role in the post-fertilization block to polyspermy. Additional proteolytically cleavage of the N-terminal peptide of 30 kDa occurs in one-cell and two-cell embryos. N-glycosylated. O-glycosylated.contains sulfate-substituted glycans. |
| Function | Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor. |
| Protein Name | Zona Pellucida Sperm-Binding Protein 2Zona Pellucida Glycoprotein 2Zp-2Zona Pellucida Protein A Cleaved Into - Processed Zona Pellucida Sperm-Binding Protein 2 |
| Database Links | Reactome: R-HSA-2534343 |
| Cellular Localisation | Processed Zona Pellucida Sperm-Binding Protein 2: Zona PellucidaCell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Zona Pellucida Sperm-Binding Protein 2 antibodyAnti-Zona Pellucida Glycoprotein 2 antibodyAnti-Zp-2 antibodyAnti-Zona Pellucida Protein A Cleaved Into - Processed Zona Pellucida Sperm-Binding Protein 2 antibodyAnti-ZP2 antibodyAnti-ZPA antibody |
Information sourced from Uniprot.org
