• Immunofluorescence analysis of A549 cells, using ZNRF2 Antibody. The picture on the right is blocked with the synthesized peptide.

Anti-ZNRF2 antibody (161-210 aa) (STJ96351)

SKU:
STJ96351

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: IHC/IF/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-E3 ubiquitin-protein ligase ZNRF2 (161-210 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ZNRF2
Gene ID: 223082
Uniprot ID: ZNRF2_HUMAN
Immunogen Region: 161-210 aa
Specificity: ZNRF2 Polyclonal Antibody detects endogenous levels of ZNRF2 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human ZNRF2 at the amino acid range 161-210
Post Translational Modifications Phosphorylated.leading to binding to YWHAE. Phosphorylated by MTOR at Ser-145 and dephosphorylated by PP6C. Ser-145 phosphorylation stimulates vesicle-to-cytosol translocation.
Function E3 ubiquitin-protein ligase that plays a role in the establishment and maintenance of neuronal transmission and plasticity. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation. Acts also as a positive regulator of mTORC1 activation by amino acids, which functions upstream of the V-ATPase and of Rag-GTPases. In turn, phosphorylation by mTOR leads to its inhibition via targeting to the cytosol allowing a self-regulating feedback mechanism.
Protein Name E3 Ubiquitin-Protein Ligase Znrf2
Protein Ells2
Ring Finger Protein 202
Ring-Type E3 Ubiquitin Transferase Znrf2
Zinc/Ring Finger Protein 2
Database Links Reactome: R-HSA-983168
Cellular Localisation Endosome Membrane
Peripheral Membrane Protein
Lysosome Membrane
Presynaptic Cell Membrane
Cytoplasm
Alternative Antibody Names Anti-E3 Ubiquitin-Protein Ligase Znrf2 antibody
Anti-Protein Ells2 antibody
Anti-Ring Finger Protein 202 antibody
Anti-Ring-Type E3 Ubiquitin Transferase Znrf2 antibody
Anti-Zinc/Ring Finger Protein 2 antibody
Anti-ZNRF2 antibody
Anti-RNF202 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance