| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Zfp541 (1-1363) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
Znf541 |
| Gene ID: |
666528 |
| Uniprot ID: |
ZN541_MOUSE |
| Immunogen Region: |
1-1363 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-1363 of mouse Zfp541 (NP_001092747.1). |
| Immunogen Sequence: |
MEPYSLGEEGALPSEGHLPS FSESQVLNCSDTLNRDLGPS TRDLLYAGLSGLDLDPSLST SDMPSEVLEDNLDTLSLYSG KDSDSVKLLEEYADSESQTS LQDLGLGALKVPKEADEGGR ATGSTRKGKRQHSSPQNPLL DCSLCGKVFSSASSLSKHYL THSQERKHVCKVCSKAFKRQ DHLTGHMLTHQKTKPFVCIE QGCSKSYCDYRSLRRHYEVQ HGVCILKETPPEEEAYGDP |
| Tissue Specificity | Germ-cell-specific. Specifically present in testicular spermatogenic cells, but not in testicular and mature sperm. During spermatogenesis, it is present in spermatocytes and round spermatids only (at protein level). |
| Function | Transcription regulator which is essential for male fertility and for the completion of meiotic prophase in spermatocytes. Regulates progression of the pachytene stage of meiotic prophase by activating the expression of genes involved in meiosis and post-meiosis during spermatogenesis. Maintains the repression of pre-pachytene transcriptional programs, including meiotic double-strand breaks (DSB) formation genes in pachytene spermatocytes and suppresses aberrant DSB formation after mid-pachytene, thus ensuring meiosis progression. |
| Protein Name | Zinc Finger Protein 541Spermatogenic Cell Hdac-Interacting Protein 1 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Zinc Finger Protein 541 antibodyAnti-Spermatogenic Cell Hdac-Interacting Protein 1 antibodyAnti-Znf541 antibodyAnti-Ship1 antibodyAnti-Zfp541 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
