| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Zinc finger protein 385A is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ZNF385A |
| Gene ID: |
25946 |
| Uniprot ID: |
Z385A_HUMAN |
| Specificity: |
This antibody detects endogenous levels of ZNF385A at Human |
| Immunogen: |
Synthesized peptide derived from human ZNF385A |
| Post Translational Modifications | Ubiquitinated upon prolonged exposure to genotoxic stress, which leads to proteasomal degradation of ZNF385A and releases p53/TP53 from cell-cycle arrest target gene promoters. |
| Function | RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3'-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation. |
| Protein Name | Zinc Finger Protein 385aHematopoietic Zinc Finger ProteinRetinal Zinc Finger Protein |
| Database Links | Reactome: R-HSA-6804114Reactome: R-HSA-6804116Reactome: R-HSA-6804759Reactome: R-HSA-69895 |
| Cellular Localisation | CytoplasmNucleusNucleolusCell ProjectionDendriteDetected In Dendrites Of Purkinje Cells And Hippocampal Neurons |
| Alternative Antibody Names | Anti-Zinc Finger Protein 385a antibodyAnti-Hematopoietic Zinc Finger Protein antibodyAnti-Retinal Zinc Finger Protein antibodyAnti-ZNF385A antibodyAnti-HZF antibodyAnti-RZF antibodyAnti-ZNF385 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
