| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ZMYND11 (278-567) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ZMYND11 |
| Gene ID: |
10771 |
| Uniprot ID: |
ZMY11_HUMAN |
| Immunogen Region: |
278-567 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 278-567 of human ZMYND11 (NP_997644.2). |
| Immunogen Sequence: |
PNHELVWAKMKGFGFWPAKV MQKEDNQVDVRFFGHHHQRA WIPSENIQDITVNIHRLHVK RSMGWKKACDELELHQRFLR EGRFWKSKNEDRGEEEAESS ISSTSNEQLKVTQEPRAKKG RRNQSVEPKKEEPEPETEAV SSSQEIPTMPQPIEKVSVST QTKKLSASSPRMLHRSTQTT NDGVCQSMCHDKYTKIFNDF KDRMKSDHKRETERVVREAL EKLRSEMEEEKRQAVNKAV |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Sumoylated following its interaction with PIAS1 and UBE2I. Ubiquitinated, leading to proteasomal degradation. |
| Function | Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA. Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth. (Microbial infection) Inhibits Epstein-Barr virus EBNA2-mediated transcriptional activation and host cell proliferation, through direct interaction. |
| Protein Name | Zinc Finger Mynd Domain-Containing Protein 11Adenovirus 5 E1a-Binding ProteinBone Morphogenetic Protein Receptor-Associated Molecule 1Protein Bs69 |
| Cellular Localisation | NucleusChromosomeAssociates With Chromatin And Mitotic Chromosomes |
| Alternative Antibody Names | Anti-Zinc Finger Mynd Domain-Containing Protein 11 antibodyAnti-Adenovirus 5 E1a-Binding Protein antibodyAnti-Bone Morphogenetic Protein Receptor-Associated Molecule 1 antibodyAnti-Protein Bs69 antibodyAnti-ZMYND11 antibodyAnti-BRAM1 antibodyAnti-BS69 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
