Anti-ZER1 antibody (388-438 aa) (STJ193778)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human ZER1 at the amino acid range 388-438
General Information
| Short Description | Rabbit polyclonal anti-Protein zer-1 homolog (388-438 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ZER1 |
| Gene ID | 10444 |
| Uniprot ID | ZER1_HUMAN |
| Immunogen | Synthesized peptide derived from the human ZER1 at the amino acid range 388-438 |
| Immunogen Region | 388-438 aa |
| Specificity | This antibody detects endogenous levels of ZER1 at Human/Mouse |
Additional Info
| Function | Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts to target substrates bearing N-terminal degrons for proteasomal degradation with the first four residues of substrates being the key recognition elements. Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N-myristoylation. |
| Protein Name | Protein Zer-1 HomologHzygZyg-11 Homolog B-Like ProteinZyg11b-Like Protein |
| Database Links | |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Protein Zer-1 Homolog antibodyAnti-Hzyg antibodyAnti-Zyg-11 Homolog B-Like Protein antibodyAnti-Zyg11b-Like Protein antibodyAnti-ZER1 antibodyAnti-C9orf60 antibodyAnti-ZYG antibodyAnti-ZYG11BL antibody |
Information sourced from Uniprot.org