| Short Description : | Rabbit polyclonal ZC3H14 (1-306) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ZC3H14 |
| Gene ID: | 79882 |
| Uniprot ID: | ZC3HE_HUMAN |
| Immunogen Region: | 1-306 |
| Immunogen Sequence: | MRMSSKFPSPPLPIFLPPEP VDLGSITSSSCSLNELDNIS HLLRKISADINEIKGMKAAI LTVEANLFDLNVRVSKNEAK ISSLEVKMNEYSTTYECNRQ FEDQEEDTESQSRTTDVKII GFLRNVEKGTQQRQLLSRLQ IDPVMAETLQMSQAEMSELS VAQKPEKLLERCKYWPACKN GDECAYHHPISPCKAFPNCK FAEKCLFVHPNCKYDAKCTK PDCPFTHVSRRIPVLSPKP |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-306 of human ZC3H14 (NP_997545.2). |
| Tissue Specificity | Isoform 1: Expressed in fetal and adult brain. Expressed in fetal and adult temporal lobe. Isoform 6: Expressed in fetal and adult brain. Expressed in fetal and adult temporal lobe. |
| Function | RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs. Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome. Required for spermatogenesis via involvement in circRNA biogenesis. Regulates the pre-mRNA processing of ATP5MC1.preventing its degradation. Also binds the poly(A) tail of mRNAs.controlling poly(A) length in neuronal cells. |
| Protein Name | Zinc Finger Ccch Domain-Containing Protein 14Mammalian Suppressor Of Tau Pathology-2Msut-2Renal Carcinoma Antigen Ny-Ren-37 |
| Database Links | |
| Cellular Localisation | Nucleus SpeckleColocalizes With Poly(A) Rna In Nuclear SpecklesIsoform 1: Nucleus SpeckleIsoform 3: Nucleus SpeckleIsoform 6: Cytoplasm |
| Alternative Antibody Names | Anti-Zinc Finger Ccch Domain-Containing Protein 14 antibodyAnti-Mammalian Suppressor Of Tau Pathology-2 antibodyAnti-Msut-2 antibodyAnti-Renal Carcinoma Antigen Ny-Ren-37 antibodyAnti-ZC3H14 antibody |
Information sourced from Uniprot.org
