Anti-ZC3H14 antibody (1-306) (STJ112401)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ZC3H14 (1-306) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ZC3H14 |
| Gene ID | 79882 |
| Uniprot ID | ZC3HE_HUMAN |
| Immunogen Region | 1-306 |
| Immunogen Sequence | MRMSSKFPSPPLPIFLPPEP VDLGSITSSSCSLNELDNIS HLLRKISADINEIKGMKAAI LTVEANLFDLNVRVSKNEAK ISSLEVKMNEYSTTYECNRQ FEDQEEDTESQSRTTDVKII GFLRNVEKGTQQRQLLSRLQ IDPVMAETLQMSQAEMSELS VAQKPEKLLERCKYWPACKN GDECAYHHPISPCKAFPNCK FAEKCLFVHPNCKYDAKCTK PDCPFTHVSRRIPVLSPKP |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-306 of human ZC3H14 (NP_997545.2). |
Additional Info
| Tissue Specificity | Isoform 1: Expressed in fetal and adult brain. Expressed in fetal and adult temporal lobe. Isoform 6: Expressed in fetal and adult brain. Expressed in fetal and adult temporal lobe. |
| Function | RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs. Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome. Required for spermatogenesis via involvement in circRNA biogenesis. Regulates the pre-mRNA processing of ATP5MC1.preventing its degradation. Also binds the poly(A) tail of mRNAs.controlling poly(A) length in neuronal cells. |
| Protein Name | Zinc Finger Ccch Domain-Containing Protein 14Mammalian Suppressor Of Tau Pathology-2Msut-2Renal Carcinoma Antigen Ny-Ren-37 |
| Database Links | |
| Cellular Localisation | Nucleus SpeckleColocalizes With Poly(A) Rna In Nuclear SpecklesIsoform 1: Nucleus SpeckleIsoform 3: Nucleus SpeckleIsoform 6: Cytoplasm |
| Alternative Antibody Names | Anti-Zinc Finger Ccch Domain-Containing Protein 14 antibodyAnti-Mammalian Suppressor Of Tau Pathology-2 antibodyAnti-Msut-2 antibodyAnti-Renal Carcinoma Antigen Ny-Ren-37 antibodyAnti-ZC3H14 antibody |
Information sourced from Uniprot.org